Nowadays industrial components modules products and systems are complex in design and manufacturing. They are commonly used in smart manufacturing and smart city with mission-critical applications. Their reliability and safety are the key concerns from both manufacturer and user prospective. Combining with physics-based methodologies AI-based data-driven technologies are the promising new approaches in anomaly diagnostics and prognostics for addressing real-life reliability and safety issues. In this technical seminar technology leaders from industry and academia will have valuable sharing on their practical experience technology trends and insights in details.