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Covid-19: Meeting the challenges through Engineering

I was president of the IET for 2016-17, and have been asked by government to gather practical and innovative ideas from our Engineering communities. So, please enter any ideas you might have in this thread that might help address and mitigate the Covid-19 crisis. Ideas might include digital tracking / monitoring through therapy equipment and beyond. Even ideas outside your usual expertise domain will be welcome. Now’s the time for Engineering to show we can change the world!
  • Former Community Member
    0 Former Community Member
    Hi

    Bear in mind that many masks have an aluminium strip to make the mask fit round the nose


  • CreativeImpulse:

    Hi Kenneth,


     My concern would be a microwave would destroy the static electric deposits that filter the viral load in the ones I mentioned. I think you'd need specialist knowledge of the mechanisms used to evaluate that with microwaves.


    Regarding the cleaning of other types of mask and other PPE, I see no reason why that shouldn't be appropriate. If it were microwave proof, i.e. not going to shrivel up like a crisp packet... and didn't contain metallic hinge pins. Then in theory it should kill anything biological in pretty short order. That might offer an option for more delicate materials, the static based masks are quite solidly constructed from my brief reading. That's half the problem, you have to penetrate the mask to sterilise it at depth. However, something lighter and less solid, with no EM involvement should be suitable for a microwave. The question will be whether the Covid is heated due to it's own molecular construct/carrier construct being excited by the RF, or whether it is heated by the material it's on being heated. If the material has to reach high temperatures, that could be a problem. If the Covid itself is heated by the RF, then you could blast it quite quickly with an industrial microwave such as you'd probably find in most hospital kitchens.


    Of course, we are in a hospital... we have X-ray generators! Could these be (ab)used?

    I think at this point we need the input of an RF expert with biological expert.


    Cheers


    Rob





    Kenneth Hattersley:

    Good point. Has this ref any validity? https://consteril.com/covid-19-pandemic-disinfection-and-sterilization-of-face-masks-for-viruses/.


    This claims the simple "single use" "mask is not cleanable but that two more complex masks are.


    Does anyone know if a microwave would directly neutralise COVID19 (or other ) viruses held in fabric / plastic mask filters?


    The reference above mentions microwaves in terms of generating heat from a water bath, on which a mask is placed.


    If there was a clinically approved method it could be useful.




     


     




    Msrs Impulse and Hattersley 

           Electromagnetic radiation will only 'heat' things which are larger than one quarter of it wavelength ... can perform as an antennae. A typical microwave oven operating at 2.4GHz has a wavelength of 12cm, so the smallest thing it can heat is about 3cm (Yes, that's right). To heat a virus to a point at which it would be damaged would require exposure to appropriate scale wavelengths. As apparently, viruses vary in size from 20nm - 400nm to damage them by radiation you need adequately high levels of radiation in the nm spectrum. UV-C, X-Ray and Gamma radiation are in the spectrum 10nm down to 0.1nm. And as we know these are dangerous to humans, as they damage the content of our cells.

  • Hello Ian and all. Ian good luck with the ambulance application.


    After online searches, I find many accounts in general of positive results of using Ozone for sterilization. Long standing method by all accounts, nothing new under the sun.

    Another manufacturer - this is for Ozone odour control - could this be extended to mass sterilization? https://www.ozonecleanair.co.uk/product/ozone-cabinet/


    To aid this (IET) cause, I am looking specifically for objective evidence that 1) Ozone can be used successfully to sterilize materiel like masks / small equipment / fabrics to high enough standards, 2) what the standards are, and 3) what the exposure conditions need to be, and importantly, 4) how de-contamination can be checked? ie. how would you know that C-19 has been neutralized at the surface of a material - what's the test? . 


    for 1)  I do find some credible sources with summaries; but two: 

    1) https://link.springer.com/article/10.1007/s12247-017-9308-7
    2) https://www.cdc.gov/infectioncontrol/guidelines/disinfection/sterilization/other-methods.html
    “…….The ozone process is compatible with a wide range of commonly used materials including stainless steel, titanium, anodized aluminum, ceramic, glass, silica, PVC, Teflon, silicone, polypropylene, polyethylene and acrylic. In addition, rigid lumen devices of the following diameter and length can be processed: internal diameter (ID): > 2 mm, length ≤ 25 cm; ID > 3 mm, length ≤ 47 cm; and ID > 4 mm, length ≤ 60 cm.
    The process should be safe for use by the operator because there is no handling of the sterilant, no toxic emissions, no residue to aerate, and low operating temperature means there is no danger of an accidental burn. The cycle is monitored using a self-contained biological indicator and a chemical indicator. The sterilization chamber is small, about 4 ft3 (Written communication, S Dufresne, July 2004)…..”


    Which look encouraging however some issues for me to take further -  many of the papers are only fully accessible by purchase. Plus I have no expertise in this field to comment on the data and info in the documents. I'll continue, perhaps others in the community with access to relevant expertise could expand the evaluation.


    I realise that there are many steps to qualify before you can justify for mass use, but these are what I think are the first key steps.


    In passing, I note from several accounts that ozone can be produced (of course) by corona discharge. What poetry.


    Best Regards


  • Kenneth Hattersley: (It would be nice if you included something about yourself) Re the possibility of using ozone to sterilise masks and face guards.


    The ozone generators I illustrate are commercial equipment designed primarily for freshening rooms ... But they are ozone generators, and the OC1500 produces enough to be hazardous to people. These are not medically rated or calibrated, but my belief is that in a closed space these should be capable of producing enough ozone to be effective ... But confirming that would have to be established in a trial including the ambulance and medical people. But by re-purposing off-the-shelf equipment a trial could be done in days, and if successful deployed widely within a couple of weeks ... very much the timescale that COVID-19 needs. Which is why the Ambulance trial is so important, and will remain my focus.


    However, whilst masks, visors and gowns would seem very simple problem by comparison to ambulances, I think this is not the case! The mask/visors/gowns to be processed must be considered to have been contaminated, and thus will have to have been cleaned enough to be guaranteed contamination free when pressed against a healthy person for protracted time. This is a very stringent requirement for once-used materials; though easily met with new materials!


    To use an ozone technique. The used masks/visors/gowns would have to be assessed, folded, batched, loaded into the equipment then subjected to the ozone; then it must be packaged for transport to users, without getting cross-contamination from the untreated material coming in. These are all complex steps and thus slow and expensive. I suggest a more effective approach can be found in the food industry. Food Irradiation Technology (https://www.fda.gov/food/buy-store-serve-safe-food/food-irradiation-what-you-need-know), which has apparently been in use in the food industry for many years. I also understand it is in use in sterilisation of medical equipment. In this approach, masks/visors/gowns could be assessed, assembled in bundles and then shrink-wrapped! Then the complete package would be irradiated, and when the process is complete the shrink-wrap packaging maintains the biological integrity until it reaches the point of use.


    Returning to the Ambulance: The interior only needs to be as clean (or cleaner) than it would be if it were wiped with antiseptic wipes ... good but not perfect. It is an infection control process, managing the levels of viruses to the point at which the risk of a patient catching something is low enough to make the ambulance journey acceptable.


       ... I hope that helps you in your mission. 


    KeepWell.ian

  • Hello Mr Phillips.


    The use of Ozone for sterilization is new to me but of interest - potentially - for the sterilzation of face masks and other materiel - which has been a topic for a couple of us in this forum..


    The premise is  that if paper, plastic masks and eyeshields etc - even a proportion - could be recycled back into usage, this could save resources and help make kit available at this time of vast demand.


    Using ozone would appear to be relatively low cost to generate and set up a sterilizing environment for smaller objects such as face masks, gowns, etc. using the Ozone Clean type equipment - if it works.


    See this and other refs.. Are these trustable though -
    https://clinmedjournals.org/articles/jide/journal-of-infectious-diseases-and-epidemiology-jide-6-113.php?jid=jide

    Would it be possible to ask of the MD what credible evidence there could be that Ozone works on fabrics, plastics (and other materials such as eye masks) with COVID-19? e.g are there any authenticated papers perhaps on neutralizing COVID-SARS -02? And if so what are the specifics however for achieving a sterilization environment - time / concentrations - could it be as simple as running the ozone generator in a chamber with the objects to be cleaned? If it works, what could be the downsides?



    Hopefully regards, KenH






    Ian Phillips
    :
    Re: COVID-19: Call for rapid sanitising technology for ambulances.

    To sanitise all the internal surfaces of an ambulance in significantly less time than 45min, calls for a gaseous solution, and high-levels of Ozone is the natural choice. Ozone is a naturally occurring oxidising gas, which can easily generated as required by using high voltage electricity. It is hazardous to most life-forms including bacteria and viruses and may be generated quite easily inside a confined room such as an ambulance ... and can be neutralised equally quickly for operator safety. 


    My research quickly lead to this wikipedia page on ozone and this Purozo page discussing the vulnerability of viruses to ozone. And then on to this company Ozone Clean, and its OC1500 Product. And on Sunday this week contacted the MD of the company, who confirmed everything that I hope for about ozone and their product ... including its immediate availability for trials. Ozone Clean is a UK company, the product was designed here and is made in England ... so is potentially readily scaled in production. Further, the MD is prepared to make a machine available immediately for trial. 


       ... Naturally I will pass on the MDs contact details to anybody with serious interest.


    This is equipment more usually used by general room cleaners for removing smells in hotel rooms and other public areas ... Indeed NHS is apparently already in possession of some of these, which it no doubt uses in this general cleaning role. But the potential to use this big machine in a smaller confined space to generate high levels of ozone is being overlooked; and repurposing it for sanitising is a very real and immediate possibility! 


    I realise that this is just a Forum, but I am finding it seriously difficult to talk to anybody about this idea! (I've been working on it for 5 days so far). The IET referred GOV.uk website links to a Defence and Security Accelerator (DASA) which is anticipating a Project Proposal; and the timescale associated with such, is not comparable with the Immediate Possibilities presented by this repurposing of existing equipment.


    If any of you could suggest contacts or even champion it I (we) would be most grateful.


    Thanks.ian :-)




     

  • Former Community Member
    0 Former Community Member
    The MHRA has published guidance here which includes the specification for rapidly manufactured ventilator systems mentioned above; most of the standards quoted are ISO or IEC.

    This page also helpfully advised (last time that I looked) that the British Standards Institution have made their standards on ventilators accessible free of charge.

    If you need guidance on Good Manufacturing Practice for medical devices, the ISPE is the place to look - at www.ispe.org.  

    I can't see a GAMP Guide for embedded systems (such as a controller for a ventilator) so the general GAMP 5 Guide should apply. In cases of difficulty, PM me.

    There's also a guide on Good Engineering Practice in the pharma/medical device space, and one on single use technology. 

    If you have trouble accessing https://ispe.org/publications/guidance-documents  please send a PM.

    Ian CK
  • Re: COVID-19: Call for rapid sanitising technology for ambulances.

    To sanitise all the internal surfaces of an ambulance in significantly less time than 45min, calls for a gaseous solution, and high-levels of Ozone is the natural choice. Ozone is a naturally occurring oxidising gas, which can easily generated as required by using high voltage electricity. It is hazardous to most life-forms including bacteria and viruses and may be generated quite easily inside a confined room such as an ambulance ... and can be neutralised equally quickly for operator safety. 


    My research quickly lead to this wikipedia page on ozone and this Purozo page discussing the vulnerability of viruses to ozone. And then on to this company Ozone Clean, and its OC1500 Product. And on Sunday this week contacted the MD of the company, who confirmed everything that I hope for about ozone and their product ... including its immediate availability for trials. Ozone Clean is a UK company, the product was designed here and is made in England ... so is potentially readily scaled in production. Further, the MD is prepared to make a machine available immediately for trial. 


       ... Naturally I will pass on the MDs contact details to anybody with serious interest.


    This is equipment more usually used by general room cleaners for removing smells in hotel rooms and other public areas ... Indeed NHS is apparently already in possession of some of these, which it no doubt uses in this general cleaning role. But the potential to use this big machine in a smaller confined space to generate high levels of ozone is being overlooked; and repurposing it for sanitising is a very real and immediate possibility! 


    I realise that this is just a Forum, but I am finding it seriously difficult to talk to anybody about this idea! (I've been working on it for 5 days so far). The IET referred GOV.uk website links to a Defence and Security Accelerator (DASA) which is anticipating a Project Proposal; and the timescale associated with such, is not comparable with the Immediate Possibilities presented by this repurposing of existing equipment.


    If any of you could suggest contacts or even champion it I (we) would be most grateful.


    Thanks.ian :-)
  • Amazing, simple face shield design: low cost, few materials, quick to 3D print clips.
    c6bcfc7262c0897d18db089bc89aac15-huge-2020-04-08-17_22_35-covid-shield-revision3.-layout-002.pdf---adobe-acrobat-pro-dc.png


    Please share and help get this out there.


    Support needed to:
    • 3D-print & supply

    • Transition to injection moulding (bulk manufacture, sterile)

    • Fast track NHS approval

    • Conduct official testing

    For info and offers of help, contact Iain Mitchell iain1mm@yahoo.co.uk



  • 3M responded quickly. This from 3M site:
    https://multimedia.3m.com/mws/media/1816576O/disinfection-of-disposable-respirators-technical-bulletin.pdf

    And from HSE:
    https://www.hse.gov.uk/pubns/priced/hsg53.pdf


    Also ( not read) https://www.cdc.gov/coronavirus/2019-ncov/hcp/ppe-strategy/decontamination-reuse-respirators.html

  • Former Community Member
    0 Former Community Member
    Talking to my GP friend, apparently the NHS are very resistant to talk about the sterilisation and reuse of the masks and PPE. Despite many solutions being potentially on offer. In our brief chat we discussed X-Ray, Gamma Radiation Exposure and Microwave.


    X Ray has some pedigree, but I have no idea if a typical hospital machine could deliver enough energy, or whether it's a case of prolonging exposure to compensate.

    https://www.medicaldevice-network.com/projects/x-ray-sterilization/


    It seems the issue may be more political, than practical following our chat. He has some P3 masks himself... He's not allowed to use them as they insist on using single use fabric ones, not due to effectiveness but due to the knowledge they are sterile. Suggestions of sterilisation techniques have apparently fallen on deaf ears. Maybe the IET approaching the Royal College of Surgeons and asking about the problem might encourage engagement.