Nasa's SpaceX Crew-6 mission lifted off at 12:34am EST (05:34am GMT) from the Kennedy Space Center in Cape Canaveral, Florida.
The mission has seen the arrival of the first person of Arab origin intending to stay for an extended time in the ISS, as part of a six-month-long science mission that will study microgravity. UAE's first-ever astronaut launched to orbit in 2019 aboard a Russian spacecraft.
The SpaceX launch vehicle consisted of a Falcon 9 rocket topped with an autonomously operated Crew Dragon capsule called Endeavour. Onboard were Nasa's retired Navy submariner Stephen Bowen and Woody Hoburg, the United Arab Emirates' Sultan Al Neyadi, and Russian cosmonaut Andrey Fedyaev.
Fedyaev is the second cosmonaut to fly aboard an American spacecraft under a renewed ride-sharing deal between Nasa and Russia's Roscosmos, despite heightened international tensions over Russia's invasion of Ukraine.
"Once more unto the breach, dear...